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INTELLIPHARM® PKCR software simulates drug dissolution, absorption, and
pharmacokinetics. The software combines state of the art simulation of
drug dissolution with a one or two compartment pharmacokinetic model.
Resulting simulations are based on both physical and
pharmacokinetic drug properties. Features include the following:
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Dissolution based on Noyes-Whitney theory
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Simulation under sink and non-sink conditions- the
concentration of drug in bulk solution is continually updated
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Dissolution of a polydisperse drug powder
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Option to continually change solubility,
dissolution volume, and absorption rate constant to simulate precipitation,
water absorption, and changing permeability along the length of the intestine
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Continually changing surface area as drug
dissolves or precipitates
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Simulation of controlled-release
View interface
Simulated data is outputted automatically
to an Excel®
spreadsheet for easy graphing and manipulation. Outputs include:
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Solid drug in the gastrointestinal tract
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Dissolved drug in the gastrointestinal
tract
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Absorbed drug
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Percent of dose absorbed
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Drug concentration in the blood
compartment
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Drug solubility
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Absorption rate constant
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Dissolution volume
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Input parameters
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Initial particle size and mass
distribution
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Release rate
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