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Software & Consulting For The Pharmaceutical Scientist |
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Kevin C. Johnson graduated from Cadillac Senior High in 1976 as co-valedictorian and from Kalamazoo College in 1980 with a BA in chemistry. His senior thesis entitled "The effect of Chain Length on the Stabilization Due to Self-Association of Steroid 21-Hemiesters" was completed at the Upjohn Company under the direction of Dr. Bradley D. Anderson. In the fall of 1980, Kevin began his graduate studies in Pharmaceutics at the University of Wisconsin under the direction of Prof. Gordon L. Amidon. Following Prof. Amidon through two career moves, Kevin attended the Universities of Kansas and Michigan and received his Ph.D. in Pharmaceutics from the University of Michigan in 1986. His thesis title was "The Design Of Amino Acid Prodrugs For Intestinal Brush Border Enzymes". In the spring of 1986, Kevin joined Pfizer in Groton, CT in the Department of Pharmaceutical R&D. While at Pfizer, his research focused on predicting drug dissolution and absorption as well as content uniformity. In 1998, he was awarded the Pfizer Central Research Achievement Award and left Pfizer in 1999 to found Intellipharm, LLC. Kevin also taught Pharmacokinetics 245C to second year pharmacy students at the University of Connecticut during the fall semesters of 2003 and 2004. Beginning in 2008, Kevin has joined the Editorial Advisory Board of the Journal of Pharmaceutical Sciences. Publications: Kevin C. Johnson, "Dissolution: Fundamentals of In Vitro Release and the Biopharmaceutics Classification System" in Pharmaceutical Product Development In Vitro-In Vivo Correlation, edited by Dakshina Murthy Chilukuri, Gangadhar Sunkara, and David Young, copyright 2007 by Informa Healthcare USA, Inc. ISBN 10:0-8493-3827-1. Kevin C. Johnson, "Dissolution and Absorption Modeling: Model Expansion to Simulate the Effects of Precipitation, Water Absorption, Longitudinally Changing Intestinal Permeability, and Controlled Release on Drug Absorption," Drug Dev. Ind. Pharm, 29 (2003) 833-842. Ying Zhang and Kevin C. Johnson, "Effect of Drug Particle Size On Content Uniformity of Low-Dose Solid Dosage Forms," Int. J. Pharm., 154 (1997) 179-183. Kevin C. Johnson and Archie C. Swindell, "Guidance In The Setting Of Drug Particle Size Specifications To Minimize Variability In Absorption," Pharm. Res., 13 (1996) 1794-1797. Allan T. K. Lu, Mary E. Frisella, and Kevin C. Johnson, "Dissolution Modeling: Factors Affecting the Dissolution Rates of Polydisperse Powders," Pharm. Res., 10 (1993) 1308-1314. Rebecca J. Hintz and Kevin C. Johnson, "The effect of particle size distribution on dissolution rate and oral absorption," Int. J. Pharm., 51 (1989) 9-17. D. Fleisher, K. C. Johnson, B. H. Stewart, and G. L. Amidon, "Oral Absorption of 21-Corticosteroid Esters: A Function of Aqueous Stability and Intestinal Enzyme Activity and Distribution," J. Pharm. Sci., 75 (1986) 934-939. Kevin Johnson, Gordon L. Amidon, and Stefano Pogany, "Solution Kinetics of a Water-Soluble Hydrocortisone Prodrug: Hydrocortisone-21-lysinate," J. Pharm. Sci., 74 (1985) 87-89. B. D. Anderson, R. A. Conradi, and K. Johnson, "Influence of Premicellar and Micellar Association on the Reactivity of Methylprednisolone 21-Hemiesters in Aqueous Solution," J. Pharm. Sci., 72 (1983) 448-454. Presentations: "Dissolution Theory" presented at the Dissolution Testing in Pharmaceutical Analysis Conference on April 3, 2006 in Toronto, Canada sponsored by the International Pharmaceutical Academy. "What to do with Solubility, Permeability, and Dose Information" presented at the Formulation Development Conference on July 26, 2005 at the Ritz Carlton, Philadelphia, PA sponsored by the Institute For International Research. "Evaluating the Importance of Solubility on Drug Selection and Development" presented at the Strategies for Improving Solubility on June 2, 2004 at the Airport Marriott, Philadelphia, PA sponsored by Barnett International. "Particle Size and Blending: A Case Study" presented at the Pharmaceutical Particle Size Conference on March 23, 2004 at the Park Hyatt Hotel, Philadelphia, PA sponsored by Barnett International. “Modeling Drug Dissolution, Absorption, and Pharmacokinetics: Application to Formulation Development and Drug Selection” presented at the Oral Drug Delivery Summit on September 29, 2003 at the Doubletree Hotel, Philadelphia, PA sponsored by the Center for Pharmaceutical Training. “Prediction models for drug absorption” presented at the British Pharmaceutical Conference & Exhibition on September 16, 2003 at the Harrogate International Centre, Harrogate, UK. “Investigating the Scientific Rationale Guiding the Decision to Micronize” presented at Micronizing and Particle Size Reduction Conference on June 23, 2003 at the Park Hyatt, Philadelphia, PA sponsored by Barnett International. “Case Study: Particle Size and Blending” presented at the Particle Size Analysis AAPS Workshop on April 30, 2003 at the Crystal Gateway Marriott, Arlington, VA. "Investigating the Scientific Rationale Guiding the Decision to Micronize" presented at the Emerging Trends in Micronizing and Particle Size Reduction Conference on June 23, 2003 at the Park Hyatt in Philadelphia, PA sponsored by Barnett International. "Understanding the Basics in Drug Product Development" presented at the Dissolution, Bioequivalence & Bioavailability Conference on February 3, 2003 at the Park Hyatt Hotel, Philadelphia, PA sponsored by Barnett International. "Pharmaceutical Modelling: Guidance in Formulation Development and Drug Selection" presented as a poster at the AAPS Pharmaceutics and Drug Delivery Conference on April 23-4, 2002 in Arlington, VA. "Designed-In Quality: Setting Drug Particle Size Specifications to Ensure Good Content Uniformity and Dissolution" presented at 3rd Annual Blend Uniformity Validation Conference on December 4th, 2001 in Arlington, VA. "Understanding the Effect of Drug Particle Size on Dissolution and Guidance in Setting Particle Size Specifications" presented at The Dissolution Testing Conference on September 25, 2001 in Philadelphia, PA. "Hydrodynamics of Dissolution" presented at the AAPS Dissolution Workshop on May 7, 2001 in Arlington, VA "The Effect of Particle Size on Dissolution, Absorption, and Content Uniformity" presented at the University of Connecticut School of Pharmacy on September 14, 2000 in Storrs, CT. "Effect of Particle Size on Dissolution and Content Uniformity of Tablets" presented the Eastern Meeting of AAPS on June 23, 2000 in Parsippany, NJ. "Setting Drug Particle Size Specifications to Improve Content Uniformity" presented at the Blend Uniformity Validation Conference on February 29, 2000 in Philadelphia, PA. "Guidance in the Setting of Drug Particle Size Specifications to Minimize Variability in Absorption and Improve Content Uniformity" presented at the Solid Dosage Forms Conference on April 28, 1999 in Princeton, NJ. "Control of Particle Size for Dissolution and Content Uniformity" presented at the 40th Annual International Industrial Pharmaceutical Research and Development Conference on June 4, 1998 in Merrimac, WI. "The Effects of Particle Size on Dissolution and Oral Absorption: Theoretical Simulations" presented at the 27th Annual Meeting of The Fine Particle Society on August 7, 1996 in Chicago, IL. "Absorption Prediction: Comparison of Physical-Chemical Based Models" presented at the AAPS Annual Meeting on November 8, 1995 in Miami Beach, FL. "Effect of Particle Size Distribution on Dissolution Rate and Oral Absorption" presented at the 24th Annual Meeting Of The Fine Particle Society on August 27, 1993 in Chicago, IL. "Predictive Models of Drug Absorption" presented at the 35th Annual International Industrial Pharmaceutical Research and Development Conference between June 7-11, 1993 in Merrimac, WI. "The Effect of Dissolution Rate on Drug Disposition from Oral Dosages" presented at the Pharmaceutics Alumni Seminar at the University of Michigan on October 18, 1991 in Ann Arbor, MI. "Computer Simulated Effect of Particle Size Distribution on Drug Disposition" presented at the AAPS Annual Meeting on October 23, 1989 in Atlanta, GA. |
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